USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PLEK_HUMAN USC-OGP 2-DE database:  PLEK_HUMAN PLEK_HUMAN General information about the entry View entry in simple text format Entry name PLEK_HUMAN Primary accession number P08567 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Pleckstrin; AltName: Full=Platelet 47 kDa protein; Short=p47;. Gene name Name=PLEK Synonyms=P47 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0395: pI=5.99; Mw=45106 SPOT OGP-0399: pI=6.01; Mw=44886 SPOT OGP-0413: pI=6.41; Mw=42022 SPOT OGP-0414: pI=6.74; Mw=42022 SPOT OGP-0415: pI=6.64; Mw=41919 SPOT OGP-0416: pI=6.45; Mw=41817 SPOT OGP-0417: pI=6.49; Mw=41817 SPOT OGP-0421: pI=6.59; Mw=41613 SPOT OGP-0422: pI=6.18; Mw=41512 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0704: pI=5.74; Mw=43223 SPOT OGP-0712: pI=5.98; Mw=42057 SPOT OGP-0714: pI=5.96; Mw=41952 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0941: pI=6.20; Mw=42300 SPOT OGP-0942: pI=6.13; Mw=42101 SPOT OGP-0943: pI=6.51; Mw=42101 SPOT OGP-0945: pI=6.38; Mw=42003 SPOT OGP-0946: pI=6.62; Mw=41904 SPOT OGP-0947: pI=7.14; Mw=41904 SPOT OGP-0948: pI=7.28; Mw=41904 SPOT OGP-0949: pI=6.88; Mw=41806 SPOT OGP-0950: pI=6.98; Mw=41806 SPOT OGP-0951: pI=7.05; Mw=41806 SPOT OGP-0952: pI=7.21; Mw=41806 SPOT OGP-0953: pI=7.32; Mw=41806 Cross-references UniProtKB/Swiss-Prot P08567; PLEK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PLEK_HUMAN Primary accession number P08567 Secondary accession number(s) B2R9E8 Q53SU8 Q6FGM8 Q6FGQ1 Q8WV81 Sequence was last modified on  January 11, 2011 (version 3) Annotations were last modified on  March 15, 2017 (version 182) Name and origin of the protein Description RecName: Full=Pleckstrin; AltName: Full=Platelet 47 kDa protein; Short=p47; Gene name Name=PLEK Synonyms=P47 Encoded on Name=PLEK; Synonyms=P47 Keywords 3D-structure; Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X07743; CAA30564.1; -; mRNA EMBL CR542056; CAG46853.1; -; mRNA EMBL CR542079; CAG46876.1; -; mRNA EMBL AK313756; BAG36495.1; -; mRNA EMBL AC015969; AAX93121.1; -; Genomic_DNA EMBL CH471053; EAW99876.1; -; Genomic_DNA EMBL BC018549; AAH18549.1; -; mRNA CCDS CCDS1887.1; -; . PIR S00755; S00755; . RefSeq NP_002655.2; NM_002664.2; . UniGene Hs.468840; -; . PDB 1PLS; NMR; -; A=1-105 PDB 1W4M; NMR; -; A=121-223 PDB 1X05; NMR; -; A=235-350 PDB 1XX0; NMR; -; A=234-350 PDB 1ZM0; X-ray; 2.10 A; A/B=240-350 PDB 2CSO; NMR; -; A=116-229 PDB 2I5C; X-ray; 1.75 A; A/B/C=244-347 PDB 2I5F; X-ray; 1.35 A; A=244-347 PDBsum 1PLS; -; . PDBsum 1W4M; -; . PDBsum 1X05; -; . PDBsum 1XX0; -; . PDBsum 1ZM0; -; . PDBsum 2CSO; -; . PDBsum 2I5C; -; . PDBsum 2I5F; -; . ProteinModelPortal P08567; -; . SMR P08567; -; . BioGrid 111357; 2; . IntAct P08567; 10; . MINT MINT-8216753; -; . STRING 9606.ENSP00000234313; -; . iPTMnet P08567; -; . PhosphoSitePlus P08567; -; . BioMuta PLEK; -; . DMDM 317373523; -; . OGP P08567; -; . EPD P08567; -; . MaxQB P08567; -; . PaxDb P08567; -; . PeptideAtlas P08567; -; . PRIDE P08567; -; . DNASU 5341; -; . Ensembl ENST00000234313; ENSP00000234313; ENSG00000115956; . GeneID 5341; -; . KEGG hsa:5341; -; . UCSC uc002sen.5; human; . CTD 5341; -; . DisGeNET 5341; -; . GeneCards PLEK; -; . H-InvDB HIX0002122; -; . HGNC HGNC:9070; PLEK; . HPA HPA031838; -; . MIM 173570; gene; . neXtProt NX_P08567; -; . OpenTargets ENSG00000115956; -; . PharmGKB PA33400; -; . eggNOG ENOG410IFJ7; Eukaryota; . eggNOG ENOG410ZY9B; LUCA; . GeneTree ENSGT00390000006543; -; . HOGENOM HOG000294078; -; . HOVERGEN HBG001361; -; . InParanoid P08567; -; . KO K19993; -; . OMA FCEGYSS; -; . OrthoDB EOG091G09EY; -; . PhylomeDB P08567; -; . TreeFam TF332246; -; . Reactome R-HSA-114608; Platelet degranulation; . SIGNOR P08567; -; . ChiTaRS PLEK; human; . EvolutionaryTrace P08567; -; . GenomeRNAi 5341; -; . PRO PR:P08567; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000115956; -; . CleanEx HS_PLEK; -; . Genevisible P08567; HS; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0032587; C:ruffle membrane; IDA:BHF-UCL; . GO GO:0043325; F:phosphatidylinositol-3; 4-bisphosphate binding; IDA:BHF-UCL GO GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; . GO GO:0005080; F:protein kinase C binding; IDA:BHF-UCL; . GO GO:0031532; P:actin cytoskeleton reorganization; IDA:BHF-UCL; . GO GO:0030030; P:cell projection organization; IDA:BHF-UCL; . GO GO:0030866; P:cortical actin cytoskeleton organization; IDA:BHF-UCL; . GO GO:0002244; P:hematopoietic progenitor cell differentiation; IEP:BHF-UCL; . GO GO:0007229; P:integrin-mediated signaling pathway; IDA:BHF-UCL; . GO GO:0050849; P:negative regulation of calcium-mediated signaling; NAS:BHF-UCL; . GO GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IDA:BHF-UCL; . GO GO:0010920; P:negative regulation of inositol phosphate biosynthetic process; IDA:BHF-UCL; . GO GO:0046488; P:phosphatidylinositol metabolic process; IDA:BHF-UCL; . GO GO:0030845; P:phospholipase C-inhibiting G-protein coupled receptor signaling pathway; IDA:BHF-UCL; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0002576; P:platelet degranulation; IEP:BHF-UCL; . GO GO:0032233; P:positive regulation of actin filament bundle assembly; IDA:BHF-UCL; . GO GO:0030836; P:positive regulation of actin filament depolymerization; IDA:BHF-UCL; . GO GO:0010925; P:positive regulation of inositol-polyphosphate 5-phosphatase activity; IDA:BHF-UCL; . GO GO:0033625; P:positive regulation of integrin activation; ISS:BHF-UCL; . GO GO:0010572; P:positive regulation of platelet activation; ISS:BHF-UCL; . GO GO:0070528; P:protein kinase C signaling; ISS:BHF-UCL; . GO GO:0070560; P:protein secretion by platelet; ISS:BHF-UCL; . GO GO:0060305; P:regulation of cell diameter; IDA:BHF-UCL; . GO GO:0031529; P:ruffle organization; IDA:BHF-UCL; . GO GO:0070493; P:thrombin-activated receptor signaling pathway; IDA:BHF-UCL; . GO GO:0006904; P:vesicle docking involved in exocytosis; ISS:BHF-UCL; . Gene3D 1.10.10.10; -; 1; . Gene3D 2.30.29.30; -; 2; . InterPro IPR000591; DEP_dom; . InterPro IPR011993; PH_dom-like; . InterPro IPR001849; PH_domain; . InterPro IPR011991; WHTH_DNA-bd_dom; . Pfam PF00610; DEP; 1; . Pfam PF00169; PH; 2; . SMART SM00049; DEP; 1; . SMART SM00233; PH; 2; . SUPFAM SSF46785; SSF46785; 1; . SUPFAM SSF50729; SSF50729; 2; . PROSITE PS50186; DEP; 1; . PROSITE PS50003; PH_DOMAIN; 2; .

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